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In an era where fertility planning increasingly emphasizes efficiency and transparency, many couples considering overseas IVF often find themselves overwhelmed by complex terminology and unclear procedures. Terms like “cycle initiation,” “ovarian stimulation,” “blastocyst,” and “PGS” can easily create confusion at the outset.
What does “cycle initiation” mean
“Cycle initiation” refers to formally entering an IVF treatment cycle. After completing baseline fertility assessments, physicians design a personalized protocol based on the patient’s menstrual cycle, marking the transition from evaluation to active treatment. This stage typically includes ovarian stimulation, egg retrieval, fertilization, embryo culture, and transfer. One advantage of US–Mexico IVF is its flexible cycle design. Patients can begin stimulation domestically and travel abroad only for key procedures, significantly reducing time spent overseas and allowing for more controlled fertility planning.
Ovarian stimulation phase
Ovarian stimulation is the central phase of the IVF cycle. Medications are used to stimulate the ovaries to produce multiple mature follicles. Protocols—whether mild or minimal stimulation—are tailored based on indicators such as AMH and AFC to avoid excessive depletion of ovarian reserve. Most injections and follicle monitoring can be completed locally, while physicians abroad provide remote guidance to ensure precision. Once follicles reach the appropriate size (typically 18–22 mm), egg retrieval can be scheduled. This phase usually lasts 10–14 days.
Egg retrieval and sperm collection
Egg retrieval is typically performed within 3–7 days after arrival abroad. Conducted under anesthesia, the procedure takes about 20 minutes, followed by a short recovery period. Extended stays are not required, which helps reduce time costs. The male partner may provide a fresh sperm sample on-site. If travel is not possible, sperm can be transported to the lab approximately two weeks in advance. The laboratory then performs sperm processing and fertilization, commonly using intracytoplasmic sperm injection (ICSI), allowing effective fertilization even in cases of suboptimal sperm parameters.
Embryo culture and IVF-PGT
After fertilization, embryos are cultured in advanced laboratory conditions to the blastocyst stage (day 5–6). US–Mexico IVF programs commonly apply IVF-PGT, enabling comprehensive chromosomal screening before transfer. This step filters out abnormal embryos and retains only those with normal chromosomal profiles for transfer. It significantly improves implantation rates and healthy live birth outcomes, particularly for patients of advanced maternal age or those with prior failed cycles.
Embryo transfer
Frozen embryo transfer is generally recommended in US–Mexico IVF protocols, allowing the endometrium sufficient time to recover and improving implantation conditions. The transfer is performed under ultrasound guidance, is painless, and requires minimal time. Pregnancy testing is typically conducted 10–14 days later. If successful, subsequent care follows the same course as a natural pregnancy, with routine prenatal monitoring.

Dr. Nathan Zhang, founder of IVF USA, has led a team specializing in international assisted reproduction consulting for over a decade, providing services including egg freezing, IVF, and third-party reproduction in the United States. With nearly 20 years of experience in the global fertility field, IVF USA has expanded into Mexico early on, becoming the China-side partner of Power Fertility Center (POWER IVF). Dr. Nathan Zhang’s services now extend beyond the U.S. to include IVF and egg freezing in Mexico, Japan, Thailand, as well as regions such as Taiwan and Hong Kong, helping more individuals regain control over their reproductive timeline and move steadily toward building a complete and healthy family.